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Tchem
CASK
Peripheral plasma membrane protein CASK

Protein Summary
Description
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378154
  • ENSP00000367396
  • ENSG00000147044
  • ENST00000378163
  • ENSP00000367405
  • ENST00000421587
  • ENSP00000400526
  • ENST00000644347
  • ENSP00000494183
  • ENST00000645566
  • ENSP00000494788

Symbol
  • LIN2
  • CMG
  • FGS4
  • LIN2
  • TNRC8
  • hCASK
  • CAGH39
  • CAMGUK
  • MICPCH
  • MRXSNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.99
molecular function
0.97
transcription factor perturbation
0.97
interacting protein
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.35   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.35   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Cell-Cell communication
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Cell-Cell communication
Dopamine Neurotransmitter Release Cycle
Extracellular matrix organization
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (198)
1 – 10 of 198
LIN7C
Tbio
Novelty: 0.09220637
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
LIN7B
Tbio
Novelty: 0.19240914
p_int: 0.999999977
p_ni: 2.4e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SPATA2
Tbio
Novelty: 0.12189223
p_int: 0.999757683
p_ni: 0.000242317
Score: 0.552
Data Source: BioPlex,STRINGDB
ZNF414
Tdark
Novelty: 2
p_int: 0.998273663
p_ni: 0.001726336
p_wrong: 1e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
PTPDC1
Tdark
Family: Enzyme
Novelty: 0.65980844
p_int: 0.995712707
p_ni: 0.004287277
p_wrong: 1.5e-8
Score: 0.236
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.46153846
p_int: 0.968733452
p_ni: 0.031266545
p_wrong: 3e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
MYBPHL
Tdark
Novelty: 0.33801501
p_int: 0.924610166
p_ni: 0.075389831
p_wrong: 3e-9
Score: 0.523
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.00183456
p_int: 0.92366896
p_ni: 0.076331039
p_wrong: 1e-9
Data Source: BioPlex
KLHL2
Tbio
Novelty: 0.00508721
p_int: 0.895395715
p_ni: 0.104604278
p_wrong: 6e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
EIF1AD
Tdark
Novelty: 0.26086957
p_int: 0.886174651
p_ni: 0.113825349
Data Source: BioPlex
Publication Statistics
PubMed Score  148.35

PubMed score by year
PubTator Score  120.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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