You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NPHP4
Nephrocystin-4

Protein Summary
Description
Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378156
  • ENSP00000367398
  • ENSG00000131697
  • ENST00000489180
  • ENSP00000423747
  • ENST00000622020
  • ENSP00000481831

Symbol
  • KIAA0673
  • POC10
  • SLSN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.83
transcription factor
0.78
transcription factor binding site profile
0.77
histone modification site profile
0.74
virus perturbation
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.27   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.27   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nephrocystin 4
720707
Mouse
MGI:2384210
260305
Rat
RGD:1560172
313749
Dog
nephrocystin 4
VGNC:43920
489625
Horse
nephrocystin 4
VGNC:20838
100059842
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nephrocystin 4
Mouse
Rat
Dog
nephrocystin 4
Horse
nephrocystin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (185)
1 – 10 of 185
RPGR
Tbio
Family: Enzyme
Novelty: 0.002733
p_int: 0.999999949
p_ni: 4.3e-8
p_wrong: 8e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.99992528
p_ni: 0.000073593
p_wrong: 0.000001127
Data Source: BioPlex
SKAP1
Tbio
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999500421
p_ni: 0.000481193
p_wrong: 0.000018387
Score: 0.186
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.867278217
p_ni: 0.000721146
p_wrong: 0.132000637
Score: 0.173
Data Source: BioPlex,STRINGDB
NPHP1
Tbio
Novelty: 0.01113034
Score: 0.999
Data Source: Reactome,STRINGDB
RPGRIP1L
Tbio
Novelty: 0.00819421
Score: 0.999
Data Source: Reactome,STRINGDB
B9D2
Tbio
Novelty: 0.11310836
Score: 0.985
Data Source: STRINGDB
CC2D2A
Tbio
Novelty: 0.03684487
Score: 0.984
Data Source: STRINGDB
B9D1
Tbio
Novelty: 0.11567839
Score: 0.984
Data Source: STRINGDB
TMEM67
Tbio
Novelty: 0.02573267
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.27

PubMed score by year
PubTator Score  26.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: