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Tbio
CEP68
Centrosomal protein of 68 kDa

Protein Summary
Description
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260569
  • ENSP00000260569
  • ENSG00000011523
  • ENST00000377990
  • ENSP00000367229

Symbol
  • KIAA0582
  • KIAA0582
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor binding site profile
0.81
transcription factor perturbation
0.8
histone modification site profile
0.7
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.1
95.3
triglyceride measurement
3
2
4
89.2
3
1
0
1.1
84
sex hormone-binding globulin measurement
2
1
2
77.2
testosterone measurement
1
1
1
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
95.3
triglyceride measurement
4
89.2
0
1.1
84
sex hormone-binding globulin measurement
2
77.2
testosterone measurement
1
46.2
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (34)
1 – 10 of 34
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.999761526
p_ni: 0.00000153
p_wrong: 0.000236943
Score: 0.351
Data Source: BioPlex,STRINGDB
LGALSL
Tbio
Novelty: 0.02633185
Score: 0.727
Data Source: STRINGDB
COMMD1
Tbio
Novelty: 0.01349432
Score: 0.675
Data Source: STRINGDB
UGP2
Tbio
Family: Enzyme
Novelty: 0.00760963
Score: 0.673
Data Source: STRINGDB
LRRC43
Tdark
Novelty: 8.04878049
Score: 0.668
Data Source: STRINGDB
CDK5RAP2
Tbio
Novelty: 0.00956263
Score: 0.665
Data Source: STRINGDB
PRKAR2A
Tbio
Family: Enzyme
Novelty: 0.06183318
Score: 0.65
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.639
Data Source: STRINGDB
TMEM116
Tdark
Novelty: 1.81767497
Score: 0.626
Data Source: STRINGDB
NEURL1
Tbio
Family: Enzyme
Novelty: 0.05370537
Score: 0.624
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.28

PubMed score by year
PubTator Score  9.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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