You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SLC17A4
Probable small intestine urate exporter

Protein Summary
Description
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377905
  • ENSP00000367137
  • ENSG00000146039
  • ENST00000397076
  • ENSP00000380266
  • ENST00000439485
  • ENSP00000391345

Symbol
  • KAIA2138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
molecular function
0.7
phenotype
0.51
cell line
0.46
microRNA
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
2
88.9
urinary metabolite measurement
1
2
2
88.9
thyroxine measurement
1
1
1
65.3
blood metabolite measurement
1
1
1
50.5
1
1
0
1.1
41
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
88.9
urinary metabolite measurement
2
88.9
thyroxine measurement
1
65.3
blood metabolite measurement
1
50.5
0
1.1
41
Protein-Protein Interactions (41)
1 – 10 of 41
SLC16A9
Tbio
Family: Transporter
Novelty: 0.06564904
Score: 0.683
Data Source: STRINGDB
SLC34A1
Tbio
Family: Transporter
Novelty: 0.00805088
Score: 0.675
Data Source: STRINGDB
SLC37A1
Tbio
Family: Transporter
Novelty: 0.11329328
Score: 0.669
Data Source: STRINGDB
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
Score: 0.655
Data Source: STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
Score: 0.594
Data Source: STRINGDB
SLC23A3
Tdark
Family: Transporter
Novelty: 0.26061161
Score: 0.58
Data Source: STRINGDB
ZHX2
Tbio
Family: TF
Novelty: 0.01370086
Score: 0.553
Data Source: STRINGDB
PINX1
Tbio
Family: TF
Novelty: 0.01237398
Score: 0.55
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01343595
Score: 0.545
Data Source: STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
Score: 0.538
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.76

PubMed score by year
PubTator Score  5.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: