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Tbio
SLC3A2
4F2 cell-surface antigen heavy chain

Protein Summary
Description
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocys ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338663
  • ENSP00000340815
  • ENSG00000168003
  • ENST00000377889
  • ENSP00000367121
  • ENST00000377890
  • ENSP00000367122

Symbol
  • MDU1
  • 4F2
  • CD98
  • MDU1
  • 4F2HC
  • 4T2HC
  • NACAE
  • CD98HC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
virus perturbation
1
molecular function
0.98


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.06   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 1010   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.06   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 3 member 2
VGNC:11656
451271
Macaque
solute carrier family 3 member 2
722218
Mouse
MGI:96955
17254
Rat
RGD:3073
50567
Dog
solute carrier family 3 member 2
VGNC:46410
483777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 3 member 2
Macaque
solute carrier family 3 member 2
Mouse
Rat
Dog
solute carrier family 3 member 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08195-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Disease
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (143)
1 – 10 of 143
MGAT4B
Tbio
Family: Enzyme
Novelty: 0.11244606
p_int: 0.999875136
p_ni: 0.000124152
p_wrong: 7.12e-7
Data Source: BioPlex
LARGE1
Tbio
Family: Enzyme
Novelty: 0.02518701
p_int: 0.997355128
p_ni: 0.002494237
p_wrong: 0.000150635
Data Source: BioPlex
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
p_int: 0.995064068
p_ni: 0.004935931
Data Source: BioPlex
SEMA6A
Tbio
Novelty: 0.00624456
p_int: 0.992780362
p_ni: 0.007217376
p_wrong: 0.000002262
Data Source: BioPlex
GALNT7
Tbio
Family: Enzyme
Novelty: 0.05328171
p_int: 0.952935158
p_ni: 0.047064681
p_wrong: 1.61e-7
Data Source: BioPlex
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
p_int: 0.952649678
p_ni: 0.047350322
Data Source: BioPlex
FAM69A
Tdark
Novelty: 0.35978059
p_int: 0.951509289
p_ni: 0.048238362
p_wrong: 0.00025235
Data Source: BioPlex
POMT1
Tbio
Family: Enzyme
Novelty: 0.01971429
p_int: 0.927799188
p_ni: 0.072200812
Data Source: BioPlex
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.920922309
p_ni: 0.079077691
Data Source: BioPlex
ITGA7
Tbio
Novelty: 0.01243073
p_int: 0.912787314
p_ni: 0.087181737
p_wrong: 0.000030949
Data Source: BioPlex
Publication Statistics
PubMed Score  480.06

PubMed score by year
PubTator Score  237.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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