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Tbio
TNFRSF25
Tumor necrosis factor receptor superfamily member 25

Protein Summary
Description
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348333
  • ENSP00000314451
  • ENSG00000215788
  • ENST00000351748
  • ENSP00000326762
  • ENST00000351959
  • ENSP00000337713
  • ENST00000356876
  • ENSP00000349341
  • ENST00000377782
  • ENSP00000367013
  • ENST00000414040
  • ENSP00000404274
  • ENST00000485036
  • ENSP00000431554
  • ENST00000502588
  • ENSP00000423121
  • ENST00000502730
  • ENSP00000421976
  • ENST00000510563
  • ENSP00000424071

Symbol
  • APO3
  • DDR3
  • DR3
  • TNFRSF12
  • WSL
  • WSL1
  • DR3
  • TR3
  • DDR3
  • LARD
  • APO-3
  • TRAMP
  • WSL-1
  • GEF720
  • WSL-LR
  • PLEKHG5
  • TNFRSF12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
virus perturbation
0.85
PubMedID
0.74
tissue sample
0.66
disease
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2063.76   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2063.76   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 25
VGNC:11940
749145
Macaque
TNF receptor superfamily member 25
703744
Mouse
MGI:1934667
85030
Rat
RGD:1598206
500592
Dog
TNF receptor superfamily member 25
VGNC:47664
489632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 25
Macaque
TNF receptor superfamily member 25
Mouse
Rat
Dog
TNF receptor superfamily member 25
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q93038-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (46)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (175)
1 – 10 of 175
TNFSF15
Tbio
Novelty: 0.00225303
Score: 0.991
Data Source: Reactome,STRINGDB
TRADD
Tbio
Novelty: 0.00560091
Score: 0.984
Data Source: STRINGDB
TNFSF12
Tbio
Novelty: 0.00298471
Score: 0.981
Data Source: STRINGDB
FADD
Tbio
Novelty: 0.00137968
Score: 0.96
Data Source: STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.958
Data Source: STRINGDB
RIPK1
Tchem
Family: Kinase
Novelty: 0.00230565
Score: 0.955
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.953
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.945
Data Source: STRINGDB
CASP10
Tchem
Family: Enzyme
Novelty: 0.00724061
Score: 0.94
Data Source: STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  2063.76

PubMed score by year
PubTator Score  1015.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer