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Tdark
HMGN4
High mobility group nucleosome-binding domain-containing protein 4

Protein Summary
Description
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377575
  • ENSP00000366798
  • ENSG00000182952

Symbol
  • HMG17L3
  • NHC
  • NHC
  • HMG17L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.69
transcription factor binding site profile
0.61
PubMedID
0.58
co-expressed gene
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
8.5
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
8.5
13.7
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
high mobility group nucleosomal binding domain 4
698039
Horse
high mobility group nucleosomal binding domain 4
VGNC:18810
100053619
Cow
high mobility group nucleosomal binding domain 4
614918
Species
Name
OMA
EggNOG
Inparanoid
Macaque
high mobility group nucleosomal binding domain 4
Horse
high mobility group nucleosomal binding domain 4
Cow
high mobility group nucleosomal binding domain 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00479-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (29)
1 – 10 of 29
KLHL36
Tdark
Novelty: 1.4153425
p_int: 0.999998407
p_ni: 0.000001593
Data Source: BioPlex
H2AFY
Tbio
Novelty: 0.01150729
p_int: 0.982117302
p_ni: 0.017882689
p_wrong: 9e-9
Data Source: BioPlex
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.972520974
p_ni: 0.027479026
Data Source: BioPlex
HIST1H2AG
Tbio
Novelty: 0.03331195
p_int: 0.922552333
p_ni: 0.077447667
Score: 0.163
Data Source: BioPlex,STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
p_int: 0.887083408
p_ni: 0.031928017
p_wrong: 0.080988575
Data Source: BioPlex
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.779253526
p_ni: 0.220746474
Data Source: BioPlex
RPS28
Tbio
Novelty: 0.03303065
p_int: 0.774527595
p_ni: 0.225472405
Data Source: BioPlex
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.751452168
p_ni: 0.248547828
p_wrong: 5e-9
Data Source: BioPlex
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
Score: 0.73
Data Source: STRINGDB
C9orf64
Tdark
Novelty: 0.66704146
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.73

PubMed score by year
PubTator Score  59.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer