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Tclin
SLC22A12
Solute carrier family 22 member 12

Protein Summary
Description
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336464
  • ENSP00000336836
  • ENSG00000197891
  • ENST00000377567
  • ENSP00000366790
  • ENST00000377572
  • ENSP00000366795
  • ENST00000377574
  • ENSP00000366797
  • ENST00000473690
  • ENSP00000438437

Symbol
  • OATL4
  • URAT1
  • RST
  • OAT4L
  • URAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.72
cell type or tissue
0.61
cellular component
0.57
biological term
0.54
disease
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.83   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.83   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 283
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (283)
1 – 10 of 283
CHEMBL3683287
chemical structure image
CHEMBL3688197
chemical structure image
CHEMBL3683376
chemical structure image
CHEMBL3688181
chemical structure image
CHEMBL3683300
chemical structure image
CHEMBL3683316
chemical structure image
CHEMBL3683373
chemical structure image
CHEMBL3683346
chemical structure image
CHEMBL3683299
chemical structure image
CHEMBL3683305
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
2
2
97.8
urate measurement
3
2
3
92.6
overweight body mass index status
1
1
1
47
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
2
97.8
urate measurement
3
92.6
overweight body mass index status
1
47
Pathways (9)
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) (R-HSA-5619071)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Organic anion transport
Reactome
Organic cation/anion/zwitterion transport
Name
Explore in Pharos
Explore in Source
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Disease
Disorders of transmembrane transporters
Organic anion transport
Organic cation/anion/zwitterion transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
SMAP2
Tbio
Novelty: 0.70006863
p_int: 0.999937991
p_ni: 0.000061654
p_wrong: 3.55e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
p_int: 0.777482412
p_ni: 0.222517588
Score: 0.199
Data Source: BioPlex,STRINGDB
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
Score: 0.924
Data Source: STRINGDB
SLC5A12
Tdark
Family: Transporter
Novelty: 0.12119749
Score: 0.91
Data Source: STRINGDB
SLC5A8
Tchem
Family: Transporter
Novelty: 0.00892277
Score: 0.909
Data Source: STRINGDB
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.888
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.845
Data Source: STRINGDB
SLC17A3
Tbio
Family: Transporter
Novelty: 0.04671795
Score: 0.807
Data Source: STRINGDB
NDUFA13
Tclin
Family: Enzyme
Novelty: 0.01605077
Score: 0.777
Data Source: STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00029779
Score: 0.766
Data Source: STRINGDB
Publication Statistics
PubMed Score  335.83

PubMed score by year
PubTator Score  185.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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