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Tbio
DTD1
D-aminoacyl-tRNA deacylase 1

Protein Summary
Description
Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript varia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377452
  • ENSP00000366672
  • ENSG00000125821

Symbol
  • C20orf88
  • DUEB
  • HARS2
  • DTD
  • DUEB
  • DUE-B
  • HARS2
  • pqn-68
  • C20orf88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
kinase perturbation
0.66
transcription factor binding site profile
0.66
histone modification site profile
0.65
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
3
3
74.7
worry measurement
1
1
1
57.6
alcohol use disorder measurement
1
1
1
47.7
hemoglobin measurement
1
1
1
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
74.7
worry measurement
1
57.6
alcohol use disorder measurement
1
47.7
hemoglobin measurement
1
45.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-tyrosyl-tRNA deacylase 1
VGNC:9843
458119
Macaque
D-tyrosyl-tRNA deacylase 1
700895
Mouse
MGI:1913294
66044
Rat
RGD:1311821
362227
Horse
D-tyrosyl-tRNA deacylase 1
VGNC:17330
100061946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-tyrosyl-tRNA deacylase 1
Macaque
D-tyrosyl-tRNA deacylase 1
Mouse
Rat
Horse
D-tyrosyl-tRNA deacylase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TEA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
NEK2
Tchem
Family: Kinase
Novelty: 0.0059613
p_int: 0.999665478
p_ni: 0.000334522
Score: 0.54
Data Source: BioPlex,STRINGDB
POLK
Tbio
Family: Enzyme
Novelty: 0.01378154
p_int: 0.94028146
p_ni: 0.000606267
p_wrong: 0.059112273
Score: 0.54
Data Source: BioPlex,STRINGDB
GMNC
Tbio
Novelty: 0.06300768
Score: 0.817
Data Source: STRINGDB
CDC45
Tbio
Novelty: 0.00515457
Score: 0.798
Data Source: STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.777
Data Source: STRINGDB
KAT14
Tbio
Novelty: 0.17168043
Score: 0.751
Data Source: STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
Score: 0.737
Data Source: STRINGDB
DTD2
Tbio
Family: Enzyme
Novelty: 0.15403199
Score: 0.732
Data Source: STRINGDB
RBBP9
Tchem
Family: Enzyme
Novelty: 0.08692052
Score: 0.732
Data Source: STRINGDB
TICRR
Tbio
Novelty: 0.03108018
Score: 0.702
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.00

PubMed score by year
PubTator Score  8.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer