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Tbio
POU4F1
POU domain, class 4, transcription factor 1

Protein Summary
Description
Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377208
  • ENSP00000366413
  • ENSG00000152192

Symbol
  • BRN3A
  • RDC1
  • BRN3A
  • RDC-1
  • Oct-T1
  • brn-3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
protein domain
0.85
molecular function
0.81
PubMedID
0.81
transcription factor binding site profile
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.9   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.9   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102525
18996
Opossum
POU class 4 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9218]
Xenopus
POU class 4 homeobox 1
XB-GENE-853139
100488759
Zebrafish
ZDB-GENE-000523-2
58057
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Opossum
POU class 4 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9218]
Xenopus
POU class 4 homeobox 1
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01851-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (43)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Association with Co-factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Association with Co-factors
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (99)
1 – 10 of 99
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.949
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.923
Data Source: Reactome,STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.843
Data Source: STRINGDB
RIT2
Tbio
Family: Enzyme
Novelty: 0.01672192
Score: 0.817
Data Source: STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
Score: 0.741
Data Source: STRINGDB
ATOH1
Tbio
Family: TF
Novelty: 0.00397582
Score: 0.737
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.711
Data Source: STRINGDB
OPN4
Tbio
Family: GPCR
Novelty: 0.00105995
Score: 0.692
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00494095
Score: 0.665
Data Source: STRINGDB
NEUROG2
Tbio
Family: TF
Novelty: 0.00489481
Score: 0.644
Data Source: STRINGDB
Publication Statistics
PubMed Score  246.90

PubMed score by year
PubTator Score  77.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer