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Tbio
LMAN2L
VIP36-like protein

Protein Summary
Description
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264963
  • ENSP00000264963
  • ENSG00000114988
  • ENST00000377079
  • ENSP00000366280

Symbol
  • VIPL
  • VIPL
  • MRT52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.77
virus perturbation
0.72
kinase perturbation
0.71
cell type or tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
58.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.3
Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (145)
1 – 10 of 145
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
p_int: 1
Score: 0.351
Data Source: BioPlex,STRINGDB
CNTNAP1
Tbio
Novelty: 0.00618741
p_int: 0.999995363
p_ni: 0.000004636
p_wrong: 1e-9
Data Source: BioPlex
ABCA2
Tbio
Family: Transporter
Novelty: 0.02208136
p_int: 0.999925427
p_ni: 0.000074559
p_wrong: 1.4e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
ITGA1
Tbio
Novelty: 0.00545805
p_int: 0.999528202
p_ni: 0.000075677
p_wrong: 0.000396122
Score: 0.189
Data Source: BioPlex,STRINGDB
SUSD1
Tdark
Novelty: 0.54249826
p_int: 0.998169753
p_ni: 0.001730518
p_wrong: 0.000099728
Data Source: BioPlex
TMEM245
Tdark
Novelty: 0.30094854
p_int: 0.997829176
p_ni: 0.001899667
p_wrong: 0.000271158
Score: 0.16
Data Source: BioPlex,STRINGDB
TOR1B
Tbio
Novelty: 0.00611826
p_int: 0.996892019
p_ni: 0.003107981
Score: 0.212
Data Source: BioPlex,STRINGDB
LINGO1
Tbio
Novelty: 0.00778085
p_int: 0.996592427
p_ni: 0.003407573
Data Source: BioPlex
TENM3
Tbio
Novelty: 0.0251948
p_int: 0.996004027
p_ni: 0.003995726
p_wrong: 2.46e-7
Score: 0.319
Data Source: BioPlex,STRINGDB
ANO6
Tbio
Family: IC
Novelty: 0.01288434
p_int: 0.994351075
p_ni: 0.005648925
Data Source: BioPlex
Publication Statistics
PubMed Score  22.12

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer