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Tbio
CNNM4
Metal transporter CNNM4

Protein Summary
Description
Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377075
  • ENSP00000366275
  • ENSG00000158158

Symbol
  • ACDP4
  • KIAA1592
  • ACDP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
cell type or tissue
0.76
protein domain
0.73
small molecule perturbation
0.69
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (64)
1 – 10 of 64
PTP4A1
Tchem
Family: Enzyme
Novelty: 0.02863007
p_int: 0.999623832
p_ni: 0.000376168
Score: 0.927
Data Source: BioPlex,STRINGDB
PTP4A2
Tchem
Family: Enzyme
Novelty: 0.0083639
p_int: 0.997631252
p_ni: 0.002368748
Score: 0.853
Data Source: BioPlex,STRINGDB
ARL15
Tbio
Family: Enzyme
Novelty: 0.09327102
p_int: 0.99600109
p_ni: 0.00399891
Score: 0.254
Data Source: BioPlex,STRINGDB
LRRC39
Tdark
Novelty: 0.70657884
p_int: 0.931629823
p_ni: 0.068370177
Score: 0.3
Data Source: BioPlex,STRINGDB
KLK14
Tchem
Family: Enzyme
Novelty: 0.02007434
p_int: 0.787563763
p_ni: 0.212436237
Data Source: BioPlex
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.754827675
p_ni: 0.245172325
Score: 0.167
Data Source: BioPlex,STRINGDB
COX11
Tbio
Family: Enzyme
Novelty: 0.02572582
Score: 0.922
Data Source: STRINGDB
PTP4A3
Tchem
Family: Enzyme
Novelty: 0.01185448
Score: 0.77
Data Source: STRINGDB
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
Score: 0.753
Data Source: STRINGDB
CRABP2
Tbio
Novelty: 0.0050363
Score: 0.712
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.90

PubMed score by year
PubTator Score  14.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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