You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KDM2B
Lysine-specific demethylase 2B

Protein Summary
Description
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377069
  • ENSP00000366269
  • ENSG00000089094
  • ENST00000377071
  • ENSP00000366271
  • ENST00000611216
  • ENSP00000480847

Symbol
  • CXXC2
  • FBL10
  • FBXL10
  • JHDM1B
  • PCCX2
  • CXXC2
  • Fbl10
  • PCCX2
  • FBXL10
  • JHDM1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
transcription factor binding site profile
0.87
protein domain
0.85
kinase perturbation
0.81
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.97   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.97   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
54.4
1
1
0
1
54.4
grip strength measurement
1
1
1
25.9
neutrophil percentage of leukocytes
1
1
1
24.6
Calcium channel blocker use measurement
1
1
1
18.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
54.4
0
1
54.4
grip strength measurement
1
25.9
neutrophil percentage of leukocytes
1
24.6
Calcium channel blocker use measurement
1
18.6
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (135)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (157)
1 – 10 of 157
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999899
p_ni: 1e-7
p_wrong: 1e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999999868
p_ni: 7.5e-8
p_wrong: 5.7e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.999999362
p_ni: 6.37e-7
p_wrong: 1e-9
Score: 0.933
Data Source: BioPlex,STRINGDB
FAM9B
Tdark
Novelty: 0.39508009
p_int: 0.999962434
p_ni: 0.000037565
Data Source: BioPlex
PCGF1
Tbio
Novelty: 0.06481661
Score: 0.989
Data Source: STRINGDB
BCOR
Tbio
Novelty: 0.05718292
Score: 0.977
Data Source: STRINGDB
BCORL1
Tbio
Novelty: 0.03899646
Score: 0.948
Data Source: STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.906
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.903
Data Source: STRINGDB
PCGF3
Tbio
Novelty: 0.14226976
Score: 0.822
Data Source: STRINGDB
Publication Statistics
PubMed Score  78.97

PubMed score by year
PubTator Score  34.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: