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Tbio
IL31
Interleukin-31

Protein Classes
Protein Summary
Description
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377035
  • ENSP00000366234
  • ENSG00000204671

Symbol
  • IL-31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.57
tissue sample
0.5
PubMedID
0.44
cell line
0.42
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.65   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.65   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (52)
1 – 10 of 52
IL31RA
Tbio
Novelty: 0.00737445
Score: 0.985
Data Source: Reactome,STRINGDB
OSMR
Tbio
Novelty: 0.01554974
Score: 0.974
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.933
Data Source: Reactome,STRINGDB
OSM
Tbio
Novelty: 0.00227405
Score: 0.7
Data Source: STRINGDB
IL33
Tbio
Novelty: 0.00072064
Score: 0.669
Data Source: STRINGDB
TSLP
Tbio
Novelty: 0.00140333
Score: 0.669
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.669
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.642
Data Source: STRINGDB
IL22
Tbio
Novelty: 0.0023754
Score: 0.631
Data Source: STRINGDB
IL5
Tclin
Novelty: 0.0001684
Score: 0.63
Data Source: STRINGDB
Publication Statistics
PubMed Score  266.65

PubMed score by year
PubTator Score  132.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer