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Tbio
SSX1
Protein SSX1

Protein Summary
Description
Could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376919
  • ENSP00000366118
  • ENSG00000126752

Symbol
  • SSRC
  • CT5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.72
protein domain
0.58
biological process
0.49
small molecule perturbation
0.43
biological term
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.5   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.5   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16384-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (49)
1 – 10 of 49
SS18
Tbio
Novelty: 0.00915548
Score: 0.902
Data Source: STRINGDB
SSX2IP
Tbio
Novelty: 0.01381625
Score: 0.779
Data Source: STRINGDB
ZNF117
Tdark
Family: TF
Novelty: 0.65663286
Score: 0.742
Data Source: STRINGDB
ZNF83
Tdark
Family: TF
Novelty: 0.25156127
Score: 0.719
Data Source: STRINGDB
MAGEC2
Tbio
Novelty: 0.00556176
Score: 0.708
Data Source: STRINGDB
MAGEC1
Tbio
Novelty: 0.01123023
Score: 0.689
Data Source: STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
Score: 0.685
Data Source: STRINGDB
CTAG1A
Tbio
Novelty: 0.00345306
Score: 0.67
Data Source: STRINGDB
CTAG2
Tbio
Novelty: 0.02983879
Score: 0.67
Data Source: STRINGDB
HEATR3
Tbio
Novelty: 0.08367436
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  117.50

PubMed score by year
PubTator Score  91.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer