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Tbio
MOG
Myelin-oligodendrocyte glycoprotein

Protein Summary
Description
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. (Microbial infection) Acts as a receptor for rubella virus. The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259891
  • ENSP00000259891
  • ENSG00000137345
  • ENST00000359539
  • ENSP00000352534
  • ENST00000376888
  • ENSP00000366085
  • ENSG00000204655
  • ENST00000376891
  • ENSP00000366088
  • ENST00000376894
  • ENSP00000366091
  • ENST00000376898
  • ENSP00000366095
  • ENST00000376917
  • ENSP00000366115
  • ENST00000383521
  • ENSP00000373013
  • ENSG00000237834
  • ENST00000383525
  • ENSP00000373017
  • ENST00000383630
  • ENSP00000373126
  • ENST00000383631
  • ENSP00000373127
  • ENST00000396701
  • ENSP00000379929
  • ENST00000396704
  • ENSP00000379932
  • ENST00000400669
  • ENSP00000383510
  • ENST00000400671
  • ENSP00000383512
  • ENST00000400688
  • ENSP00000383526
  • ENST00000400691
  • ENSP00000383528
  • ENST00000412760
  • ENSP00000404245
  • ENST00000414889
  • ENSP00000403380
  • ENSG00000234623
  • ENST00000415546
  • ENSP00000404149
  • ENSG00000234096
  • ENST00000417019
  • ENSP00000404537
  • ENST00000419274
  • ENSP00000411489
  • ENSG00000236561
  • ENST00000419309
  • ENSP00000395005
  • ENST00000420045
  • ENSP00000390682
  • ENST00000423895
  • ENSP00000390632
  • ENSG00000230885
  • ENST00000425145
  • ENSP00000397101
  • ENST00000426782
  • ENSP00000410699
  • ENST00000427289
  • ENSP00000414489
  • ENST00000428719
  • ENSP00000397723
  • ENST00000430264
  • ENSP00000403058
  • ENST00000430351
  • ENSP00000410268
  • ENST00000431798
  • ENSP00000410866
  • ENST00000432271
  • ENSP00000389221
  • ENST00000433500
  • ENSP00000413364
  • ENST00000434177
  • ENSP00000398197
  • ENST00000438803
  • ENSP00000414862
  • ENST00000439634
  • ENSP00000404957
  • ENST00000439884
  • ENSP00000398394
  • ENST00000440561
  • ENSP00000409534
  • ENST00000442244
  • ENSP00000391516
  • ENST00000442444
  • ENSP00000414146
  • ENST00000442629
  • ENSP00000399240
  • ENST00000444674
  • ENSP00000390469
  • ENST00000447285
  • ENSP00000401609
  • ENST00000448816
  • ENSP00000397837
  • ENST00000449096
  • ENSP00000391898
  • ENST00000452233
  • ENSP00000394873
  • ENST00000452744
  • ENSP00000389022
  • ENSG00000232641
  • ENST00000457090
  • ENSP00000415883
  • ENST00000457626
  • ENSP00000402139
  • ENST00000458179
  • ENSP00000413370
  • ENST00000490427
  • ENSP00000420350
  • ENST00000494692
  • ENSP00000417405
  • ENST00000547083
  • ENSP00000449213
  • ENST00000548017
  • ENSP00000448732
  • ENST00000550849
  • ENSP00000449683
  • ENST00000551175
  • ENSP00000448879
  • ENST00000551993
  • ENSP00000446871
  • ENST00000553111
  • ENSP00000447099

Symbol
  • BTN6
  • BTNL11
  • MOGIG2
  • NRCLP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
cell type or tissue
0.74
microRNA
0.68
gene perturbation
0.67
biological term
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2171.6   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2171.6   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (112)
1 – 10 of 112
MBP
Tbio
Novelty: 0.00016333
Score: 0.907
Data Source: STRINGDB
AQP4
Tbio
Novelty: 0.00031632
Score: 0.852
Data Source: STRINGDB
MAG
Tchem
Novelty: 0.00085621
Score: 0.832
Data Source: STRINGDB
IL17A
Tclin
Novelty: 0.00011583
Score: 0.8
Data Source: STRINGDB
MOBP
Tbio
Novelty: 0.01761387
Score: 0.8
Data Source: STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.788
Data Source: STRINGDB
ZFP57
Tbio
Family: TF
Novelty: 0.02250344
Score: 0.741
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.73
Data Source: STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
Score: 0.712
Data Source: STRINGDB
CNTN2
Tbio
Novelty: 0.00213251
Score: 0.679
Data Source: STRINGDB
Publication Statistics
PubMed Score  2171.60

PubMed score by year
PubTator Score  543.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer