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Tbio
UBIAD1
UbiA prenyltransferase domain-containing protein 1

Protein Classes
Protein Summary
Description
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376804
  • ENSP00000366000
  • ENSG00000120942
  • ENST00000376810
  • ENSP00000366006

Symbol
  • TERE1
  • SCCD
  • TERE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
cellular component
0.71
transcription factor binding site profile
0.61
microRNA
0.6
transcription factor perturbation
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.02   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.02   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UbiA prenyltransferase domain containing 1
VGNC:1716
457946
Macaque
UbiA prenyltransferase domain containing 1
714320
Mouse
MGI:1918957
71707
Rat
RGD:1309588
313706
Dog
UbiA prenyltransferase domain containing 1
VGNC:48075
487446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UbiA prenyltransferase domain containing 1
Macaque
UbiA prenyltransferase domain containing 1
Mouse
Rat
Dog
UbiA prenyltransferase domain containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y5Z9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamin K
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamin K
Metabolism of vitamins and cofactors
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (52)
1 – 10 of 52
DISP3
Tbio
Novelty: 0.09299918
Score: 0.91
Data Source: STRINGDB
FBXO2
Tbio
Novelty: 0.01578361
Score: 0.831
Data Source: STRINGDB
COQ2
Tbio
Family: Enzyme
Novelty: 0.00575853
Score: 0.815
Data Source: STRINGDB
CHST6
Tbio
Family: Enzyme
Novelty: 0.01917947
Score: 0.801
Data Source: STRINGDB
HMGCR
Tclin
Family: Enzyme
Novelty: 0.00046789
Score: 0.749
Data Source: STRINGDB
SOAT1
Tchem
Family: Enzyme
Novelty: 0.00530755
Score: 0.738
Data Source: STRINGDB
SRM
Tchem
Family: Enzyme
Novelty: 0.01583759
Score: 0.712
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.698
Data Source: STRINGDB
TACSTD2
Tbio
Novelty: 0.00297704
Score: 0.689
Data Source: STRINGDB
MTLN
Tbio
Novelty: 0.17109095
Score: 0.689
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.02

PubMed score by year
PubTator Score  46.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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