You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SP2
Transcription factor Sp2

Protein Summary
Description
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376741
  • ENSP00000365931
  • ENSG00000167182

Symbol
  • KIAA0048
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
histone modification site profile
0.86
cell type or tissue
0.79
tissue sample
0.67
transcription factor
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.87   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.87   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
47.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sp2 transcription factor
VGNC:9644
455180
Macaque
Sp2 transcription factor
694834
Mouse
MGI:1926162
78912
Rat
RGD:1592078
303499
Dog
Sp2 transcription factor
VGNC:46686
100687491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sp2 transcription factor
Macaque
Sp2 transcription factor
Mouse
Rat
Dog
Sp2 transcription factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02086-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (31)
1 – 10 of 31
LGALS3BP
Tbio
Novelty: 0.0025302
Score: 0.759
Data Source: STRINGDB
SERPINH1
Tbio
Novelty: 0.00106715
Score: 0.718
Data Source: STRINGDB
MMP28
Tbio
Family: Enzyme
Novelty: 0.01679444
Score: 0.712
Data Source: STRINGDB
RIN3
Tbio
Novelty: 0.07790793
Score: 0.626
Data Source: STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
Score: 0.574
Data Source: STRINGDB
TFB2M
Tbio
Family: Enzyme
Novelty: 0.02345237
Score: 0.548
Data Source: STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00178141
Score: 0.533
Data Source: STRINGDB
CD276
Tbio
Novelty: 0.00084069
Score: 0.526
Data Source: STRINGDB
NDST1
Tbio
Family: Enzyme
Novelty: 0.00955868
Score: 0.522
Data Source: STRINGDB
MTERF1
Tbio
Novelty: 0.00983613
Score: 0.511
Data Source: STRINGDB
Publication Statistics
PubMed Score  326.87

PubMed score by year
PubTator Score  586.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: