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Tbio
BMI1
Polycomb complex protein BMI-1

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249). This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376663
  • ENSP00000365851
  • ENSG00000168283

Symbol
  • PCGF4
  • RNF51
  • BMI1
  • PCGF4
  • RNF51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor binding site profile
0.84
microRNA
0.74
virus perturbation
0.72
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1318.18   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 855   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1318.18   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (258)
1 – 10 of 258
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999999731
p_ni: 2.69e-7
Score: 0.774
Data Source: BioPlex,Reactome,STRINGDB
PCGF2
Tbio
Novelty: 0.02148755
p_int: 0.999999568
p_ni: 4.3e-7
p_wrong: 2e-9
Score: 0.942
Data Source: BioPlex,STRINGDB
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.999998607
p_ni: 0.000001393
Score: 0.725
Data Source: BioPlex,STRINGDB
PHC1
Tbio
Novelty: 0.01530622
p_int: 0.999989138
p_ni: 0.000002139
p_wrong: 0.000008723
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
CBX7
Tchem
Family: Epigenetic
Novelty: 0.01612606
p_int: 0.999948989
p_ni: 0.000051011
Score: 0.987
Data Source: BioPlex,STRINGDB
RPL7
Tbio
Novelty: 0.00552644
p_int: 0.987665534
p_ni: 0.012334466
Score: 0.159
Data Source: BioPlex,STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
p_int: 0.98512419
p_ni: 0.01487581
Score: 0.222
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.978086087
p_ni: 0.021913913
Data Source: BioPlex
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.998
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.01943349
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  1318.18

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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