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Tbio
TLE1
Transducin-like enhancer protein 1

Protein Summary
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376499
  • ENSP00000365682
  • ENSG00000196781

Symbol
  • ESG
  • ESG1
  • GRG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.88
trait
0.86
protein domain
0.85
PubMedID
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.53   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.53   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
65.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
65.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 1
VGNC:8940
464546
Macaque
transducin like enhancer of split 1
707336
Mouse
MGI:104636
21885
Rat
RGD:1309237
362533
Dog
transducin like enhancer of split 1
VGNC:47396
476314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 1
Macaque
transducin like enhancer of split 1
Mouse
Rat
Dog
transducin like enhancer of split 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04724-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
NOTCH1 Intracellular Domain Regulates Transcription
Reactome
Repression of WNT target genes
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Repression of WNT target genes
Protein-Protein Interactions (164)
1 – 10 of 164
AES
Tbio
Novelty: 0.00818499
p_int: 0.999999998
p_ni: 2e-9
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
TLE4
Tbio
Novelty: 0.02094922
p_int: 0.99999997
p_ni: 3.1e-8
Score: 0.901
Data Source: BioPlex,Reactome,STRINGDB
HEY1
Tbio
Family: TF
Novelty: 0.0042366
p_int: 0.999999696
p_ni: 1.81e-7
p_wrong: 1.23e-7
Score: 0.648
Data Source: BioPlex,STRINGDB
RIPPLY1
Tdark
Novelty: 0.11705603
p_int: 0.999999646
p_ni: 3.54e-7
Score: 0.289
Data Source: BioPlex,STRINGDB
TBX1
Tbio
Family: TF
Novelty: 0.00154882
p_int: 0.999999587
p_ni: 2.43e-7
p_wrong: 1.7e-7
Score: 0.297
Data Source: BioPlex,STRINGDB
EN2
Tbio
Family: TF
Novelty: 0.00466947
p_int: 0.999999539
p_ni: 3.04e-7
p_wrong: 1.57e-7
Score: 0.356
Data Source: BioPlex,STRINGDB
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.99999933
p_ni: 6.7e-7
Data Source: BioPlex
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.999999286
p_ni: 7.14e-7
Score: 0.901
Data Source: BioPlex,Reactome,STRINGDB
RIPPLY2
Tdark
Novelty: 0.16163153
p_int: 0.999995914
p_ni: 0.000004086
Score: 0.317
Data Source: BioPlex,STRINGDB
TLE2
Tbio
Novelty: 0.03922169
p_int: 0.999995191
p_ni: 0.000004808
p_wrong: 1e-9
Score: 0.928
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  187.53

PubMed score by year
PubTator Score  70.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer