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Tbio
NPPB
Natriuretic peptides B

Protein Summary
Description
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal ost ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376468
  • ENSP00000365651
  • ENSG00000120937

Symbol
  • BNP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
0.84
cell type or tissue
0.81
PubMedID
0.81
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3880.17   (req: < 5)
Gene RIFs: 942   (req: <= 3)
Antibodies: 1373   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3880.17   (req: >= 5)
Gene RIFs: 942   (req: > 3)
Antibodies: 1373   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
NT-proBNP measurement
1
2
2
93
blood protein measurement
1
1
1
79.7
N-terminal prohormone brain natriuretic peptide measurement
1
1
1
31.9
cardiovascular disease biomarker measurement
1
1
1
31.1
BNP measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
NT-proBNP measurement
2
93
blood protein measurement
1
79.7
N-terminal prohormone brain natriuretic peptide measurement
1
31.9
cardiovascular disease biomarker measurement
1
31.1
BNP measurement
1
13.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide B
VGNC:1418
469801
Mouse
MGI:97368
18158
Rat
RGD:3194
25105
Dog
natriuretic peptide B
VGNC:43926
487441
Horse
natriuretic peptide B
VGNC:20845
100056123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide B
Mouse
Rat
Dog
natriuretic peptide B
Horse
natriuretic peptide B
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16860-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Thermogenesis
KEGG
Vascular smooth muscle contraction
KEGG
cGMP-PKG signaling pathway
Name
Explore in Pharos
Explore in Source
Thermogenesis
Vascular smooth muscle contraction
cGMP-PKG signaling pathway
Protein-Protein Interactions (91)
1 – 10 of 91
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.999963586
p_ni: 0.000036414
Data Source: BioPlex
TCAF2
Tbio
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999927397
p_ni: 0.000072603
Data Source: BioPlex
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
p_int: 0.999792505
p_ni: 0.000204179
p_wrong: 0.000003316
Data Source: BioPlex
RFLNB
Tbio
Novelty: 0.09562879
p_int: 0.996961602
p_ni: 0.000202663
p_wrong: 0.002835735
Data Source: BioPlex
NDUFAF5
Tbio
Family: Enzyme
Novelty: 0.13483499
p_int: 0.996831997
p_ni: 0.003167996
p_wrong: 6e-9
Data Source: BioPlex
FARS2
Tchem
Family: Enzyme
Novelty: 0.00771459
p_int: 0.964471999
p_ni: 0.035528001
Data Source: BioPlex
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
p_int: 0.894899215
p_ni: 0.105100784
Data Source: BioPlex
FAT4
Tbio
Novelty: 0.01739918
p_int: 0.892260649
p_ni: 0.107739351
Data Source: BioPlex
PMPCB
Tbio
Family: Enzyme
Novelty: 0.0244013
p_int: 0.768104022
p_ni: 0.231895978
Data Source: BioPlex
NPR3
Tchem
Novelty: 0.00227442
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  3880.17

PubMed score by year
PubTator Score  5635.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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