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Tchem
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F

Protein Summary
Description
Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Isoform 4: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations. Isoform 6: Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323022
  • ENSP00000321618
  • ENSG00000102001
  • ENST00000376251
  • ENSP00000365427
  • ENST00000376265
  • ENSP00000365441

Symbol
  • CACNAF1
  • JM8
  • OA2
  • AIED
  • COD3
  • COD4
  • JMC8
  • CORDX
  • CSNB2
  • CORDX3
  • CSNB2A
  • CSNBX2
  • Cav1.4
  • Cav1.4alpha1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cellular component
0.79
biological process
0.71
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.93   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.93   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Pathways (35)
Cardiac conduction (R-HSA-5576891)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Protein-Protein Interactions (166)
1 – 10 of 166
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.986
Data Source: Reactome,STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.986
Data Source: Reactome,STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.977
Data Source: Reactome,STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.974
Data Source: Reactome,STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.965
Data Source: Reactome,STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.11899252
Score: 0.964
Data Source: STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.963
Data Source: Reactome,STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.955
Data Source: Reactome,STRINGDB
CACNA2D3
Tbio
Family: IC
Novelty: 0.05267262
Score: 0.949
Data Source: Reactome,STRINGDB
CACNG8
Tdark
Family: IC
Novelty: 0.26770379
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  234.93

PubMed score by year
PubTator Score  123.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer