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Tbio
NUDT10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Protein Classes
Protein Summary
Description
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356450
  • ENSP00000348831
  • ENSG00000122824
  • ENST00000376006
  • ENSP00000365174

Symbol
  • APS2
  • DIPP3A
  • APS2
  • DIPP3a
  • DIPP3-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
microRNA
0.66
tissue sample
0.65
cell type or tissue
0.53
chemical
0.47


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2147931
102954
Cow
nudix hydrolase 11
785611
Zebrafish
ZDB-GENE-031010-33
378990
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
nudix hydrolase 11
Zebrafish
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of pyrophosphates in the cytosol
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (118)
1 – 10 of 118
NUDT4
Tbio
Family: Enzyme
Novelty: 0.05544881
p_int: 0.999999993
p_wrong: 7e-9
Data Source: BioPlex
NUDT3
Tbio
Family: Enzyme
Novelty: 0.06052313
p_int: 0.999999796
p_ni: 1.65e-7
p_wrong: 3.9e-8
Data Source: BioPlex
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.810250566
p_ni: 0.189749434
Data Source: BioPlex
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.7953424
p_ni: 0.126953075
p_wrong: 0.077704526
Data Source: BioPlex
RPS29
Tbio
Novelty: 0.02619305
Score: 0.748
Data Source: STRINGDB
ETF1
Tbio
Family: Enzyme
Novelty: 0.00711627
Score: 0.741
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.738
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.738
Data Source: STRINGDB
RPS13
Tbio
Novelty: 0.0019983
Score: 0.716
Data Source: STRINGDB
RPL31
Tbio
Novelty: 0.03427872
Score: 0.714
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.34

PubMed score by year
PubTator Score  34.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer