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Tbio
COL4A1
Collagen alpha-1(IV) chain

Protein Summary
Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375820
  • ENSP00000364979
  • ENSG00000187498
  • ENST00000543140
  • ENSP00000443348

Symbol
  • BSVD
  • BSVD1
  • RATOR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
1
trait
0.99
transcription factor perturbation
0.99
gene perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.33   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.33   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (69)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
4
1.1
86.7
BMI-adjusted waist-hip ratio
1
1
1
75.8
mean platelet volume
2
1
2
66.9
waist-hip ratio
1
1
1
57.1
lymphocyte count
2
1
2
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
86.7
BMI-adjusted waist-hip ratio
1
75.8
mean platelet volume
2
66.9
waist-hip ratio
1
57.1
lymphocyte count
2
50.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 1 chain
VGNC:10713
452659
Macaque
collagen type IV alpha 1 chain
700281
Mouse
MGI:88454
12826
Rat
RGD:1307148
290905
Dog
collagen type IV alpha 1 chain
VGNC:39473
403496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 1 chain
Macaque
collagen type IV alpha 1 chain
Mouse
Rat
Dog
collagen type IV alpha 1 chain
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02462-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Binding and Uptake of Ligands by Scavenger Receptors
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Protein-Protein Interactions (174)
1 – 10 of 174
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999999975
p_ni: 2.2e-8
p_wrong: 3e-9
Score: 0.948
Data Source: BioPlex,STRINGDB
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.999992999
p_ni: 0.000004838
p_wrong: 0.000002163
Data Source: BioPlex
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.999984194
p_ni: 0.000015805
p_wrong: 2e-9
Score: 0.916
Data Source: BioPlex,STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.999954443
p_ni: 0.000007532
p_wrong: 0.000038024
Score: 0.583
Data Source: BioPlex,STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
p_int: 0.999780963
p_ni: 0.000050282
p_wrong: 0.000168755
Score: 0.938
Data Source: BioPlex,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.986980779
p_ni: 0.000008989
p_wrong: 0.013010232
Score: 0.679
Data Source: BioPlex,STRINGDB
TINAG
Tbio
Novelty: 0.04582927
p_int: 0.817291139
p_ni: 0.0009771
p_wrong: 0.181731762
Score: 0.209
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
Score: 0.999
Data Source: Reactome,STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.972
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  283.33

PubMed score by year
PubTator Score  150.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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