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Tchem
CLCNKB
Chloride channel protein ClC-Kb

Protein Summary
Description
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375667
  • ENSP00000364819
  • ENSG00000184908
  • ENST00000375679
  • ENSP00000364831

Symbol
  • CLCKB
  • ClC-K2
  • ClC-Kb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.68
tissue sample
0.67
cell line
0.65
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.49   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.49   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
niflumic acid
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
45.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
45.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel Kb
VGNC:8037
456470
Macaque
chloride voltage-gated channel Ka [Source:HGNC Symbol;Acc:HGNC:2026]
Mouse
MGI:1930643
56365
Rat
RGD:628639
79430
Dog
chloride voltage-gated channel Ka
487422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel Kb
Macaque
chloride voltage-gated channel Ka [Source:HGNC Symbol;Acc:HGNC:2026]
Mouse
Rat
Dog
chloride voltage-gated channel Ka
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51801-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
BSND
Tbio
Novelty: 0.01638636
Score: 0.995
Data Source: Reactome,STRINGDB
KCNJ1
Tchem
Family: IC
Novelty: 0.0025066
Score: 0.871
Data Source: STRINGDB
SLC12A1
Tclin
Family: Transporter
Novelty: 0.00303604
Score: 0.85
Data Source: STRINGDB
SLC12A3
Tclin
Family: Transporter
Novelty: 0.00199394
Score: 0.81
Data Source: STRINGDB
ANO1
Tclin
Family: IC
Novelty: 0.00143722
Score: 0.772
Data Source: STRINGDB
KLF15
Tbio
Family: TF
Novelty: 0.009709
Score: 0.711
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00061316
Score: 0.7
Data Source: STRINGDB
ANO2
Tbio
Family: IC
Novelty: 0.01239394
Score: 0.659
Data Source: STRINGDB
TTYH1
Tbio
Family: IC
Novelty: 0.0669885
Score: 0.64
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.635
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.49

PubMed score by year
PubTator Score  90.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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