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Tclin
F10
Coagulation factor X

Protein Summary
Description
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375559
  • ENSP00000364709
  • ENSG00000126218

Symbol
  • FX
  • FXA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.99
drug
0.99
kinase perturbation
0.93
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1716.21   (req: < 5)
Gene RIFs: 231   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1716.21   (req: >= 5)
Gene RIFs: 231   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3953
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
betrixaban
chemical structure image
edoxaban
chemical structure image
rivaroxaban
chemical structure image
apixaban
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prothrombin time measurement
1
2
2
53.8
reticulocyte measurement
1
1
1
21.4
reticulocyte count
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prothrombin time measurement
2
53.8
reticulocyte measurement
1
21.4
reticulocyte count
1
13.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor X
VGNC:7830
107968009
Macaque
coagulation factor X
714132
Mouse
MGI:103107
14058
Rat
RGD:61850
29243
Dog
coagulation factor X
VGNC:40543
476993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor X
Macaque
coagulation factor X
Mouse
Rat
Dog
coagulation factor X
Protein Structure (144 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00742-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 144
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Extrinsic Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Extrinsic Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Protein-Protein Interactions (97)
1 – 10 of 97
PIP4P2
Tbio
Family: Enzyme
Novelty: 0.94294105
p_int: 0.99985562
p_ni: 0.000041382
p_wrong: 0.000102999
Data Source: BioPlex
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.997
Data Source: STRINGDB
F3
Tchem
Novelty: 0.00006457
Score: 0.992
Data Source: Reactome,STRINGDB
F5
Tbio
Novelty: 0.00161772
Score: 0.989
Data Source: Reactome,STRINGDB
TFPI
Tchem
Novelty: 0.00060355
Score: 0.987
Data Source: Reactome,STRINGDB
F8
Tbio
Novelty: 0.0002287
Score: 0.984
Data Source: Reactome,STRINGDB
SERPIND1
Tbio
Novelty: 0.00120897
Score: 0.965
Data Source: STRINGDB
F7
Tchem
Family: Enzyme
Novelty: 0.0002521
Score: 0.964
Data Source: Reactome,STRINGDB
THBD
Tbio
Novelty: 0.00039359
Score: 0.96
Data Source: STRINGDB
GGCX
Tclin
Family: Enzyme
Novelty: 0.00819484
Score: 0.959
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1716.21

PubMed score by year
PubTator Score  3277.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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