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Tbio
SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Protein Summary
Description
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375499
  • ENSP00000364649
  • ENSG00000117118

Symbol
  • SDH
  • SDH1
  • IP
  • SDH
  • CWS2
  • PGL4
  • SDH1
  • SDH2
  • SDHIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
0.97
interacting protein
0.94
co-expressed gene
0.87
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.18   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.18   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (23)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (336)
1 – 10 of 336
SDHAF3
Tbio
Family: Enzyme
Novelty: 0.01155522
p_int: 0.999999993
p_ni: 7e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
p_int: 0.998848411
p_ni: 0.001151562
p_wrong: 2.7e-8
Score: 0.245
Data Source: BioPlex,STRINGDB
D2HGDH
Tbio
Family: Enzyme
Novelty: 0.04618268
p_int: 0.995021694
p_ni: 0.004978306
Score: 0.404
Data Source: BioPlex,STRINGDB
ACAD11
Tbio
Family: Enzyme
Novelty: 0.22908145
p_int: 0.97599038
p_ni: 0.02400962
Score: 0.154
Data Source: BioPlex,STRINGDB
PDPR
Tbio
Family: Enzyme
Novelty: 0.04223174
p_int: 0.939444878
p_ni: 0.060555122
Score: 0.403
Data Source: BioPlex,STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.934051345
p_ni: 0.06594786
p_wrong: 7.95e-7
Score: 0.347
Data Source: BioPlex,STRINGDB
MMADHC
Tbio
Novelty: 0.02299238
p_int: 0.923031056
p_ni: 0.000502335
p_wrong: 0.076466609
Score: 0.326
Data Source: BioPlex,STRINGDB
HARS2
Tbio
Family: Enzyme
Novelty: 0.00230399
p_int: 0.914837049
p_ni: 0.085162951
Score: 0.368
Data Source: BioPlex,STRINGDB
PREPL
Tchem
Family: Enzyme
Novelty: 0.02310586
p_int: 0.908125385
p_ni: 0.091874615
Score: 0.184
Data Source: BioPlex,STRINGDB
SDHA
Tbio
Family: Enzyme
Novelty: 0.00223171
p_int: 0.899983622
p_ni: 0.100016378
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  894.18

PubMed score by year
PubTator Score  829.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer