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Tbio
DCAF17
DDB1- and CUL4-associated factor 17

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375255
  • ENSP00000364404
  • ENSG00000115827
  • ENST00000611110
  • ENSP00000477604

Symbol
  • C2orf37
  • C2orf37
  • C20orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
virus perturbation
0.85
transcription factor binding site profile
0.74
tissue sample
0.72
transcription factor
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 17
VGNC:161
459732
Macaque
DDB1 and CUL4 associated factor 17
695470
Mouse
MGI:1923013
75763
Rat
RGD:1565551
499807
Dog
DDB1 and CUL4 associated factor 17
VGNC:39793
609326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 17
Macaque
DDB1 and CUL4 associated factor 17
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5H9S7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (96)
1 – 10 of 96
SPATA24
Tdark
Novelty: 0.95478351
p_int: 0.999999908
p_ni: 9.1e-8
p_wrong: 1e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
HOXB6
Tbio
Family: TF
Novelty: 0.0176813
p_int: 0.999999225
p_ni: 7.72e-7
p_wrong: 3e-9
Data Source: BioPlex
ZMAT3
Tbio
Novelty: 0.04765896
p_int: 0.999997332
p_ni: 2e-9
p_wrong: 0.000002666
Score: 0.269
Data Source: BioPlex,STRINGDB
RAB40B
Tbio
Novelty: 0.2288213
p_int: 0.999994688
p_ni: 7.99e-7
p_wrong: 0.000004513
Score: 0.29
Data Source: BioPlex,STRINGDB
UBE2M
Tbio
Novelty: 0.02353106
Score: 0.922
Data Source: STRINGDB
DDB1
Tbio
Novelty: 0.00345896
Score: 0.916
Data Source: STRINGDB
DDA1
Tbio
Novelty: 0.06840858
Score: 0.914
Data Source: STRINGDB
COPS6
Tbio
Novelty: 0.02653008
Score: 0.913
Data Source: STRINGDB
CUL4B
Tbio
Novelty: 0.0133075
Score: 0.911
Data Source: STRINGDB
CUL4A
Tbio
Novelty: 0.00917788
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.63

PubMed score by year
PubTator Score  16.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer