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Tbio
HSPG2
Basement membrane-specific heparan sulfate proteoglycan core protein

Protein Classes
Protein Summary
Description
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374695
  • ENSP00000363827
  • ENSG00000142798

Symbol
  • PLC
  • SJA
  • SJS
  • HSPG
  • SJS1
  • PRCAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cellular component
0.92
biological term
0.78
transcription factor
0.74
interacting protein
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.85   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.85   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate proteoglycan 2
VGNC:52978
100613114
Macaque
heparan sulfate proteoglycan 2
707213
Mouse
MGI:96257
15530
Dog
heparan sulfate proteoglycan 2
VGNC:41820
403440
Horse
heparan sulfate proteoglycan 2
VGNC:18898
100071701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparan sulfate proteoglycan 2
Macaque
heparan sulfate proteoglycan 2
Mouse
Dog
heparan sulfate proteoglycan 2
Horse
heparan sulfate proteoglycan 2
Protein Structure (2 Structures, 16 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (106)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Amyloid fiber formation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Amyloid fiber formation
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (263)
1 – 10 of 263
TINAGL1
Tbio
Novelty: 0.05578199
p_int: 0.999999762
p_ni: 1.2e-8
p_wrong: 2.25e-7
Score: 0.591
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.999991831
p_ni: 0.000008158
p_wrong: 1e-8
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999935375
p_ni: 0.000064569
p_wrong: 5.6e-8
Data Source: BioPlex
H2BFWT
Tbio
Novelty: 0.16138632
p_int: 0.999488183
p_ni: 0.000125302
p_wrong: 0.000386515
Data Source: BioPlex
NID1
Tbio
Novelty: 0.00169075
Score: 0.996
Data Source: Reactome,STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.992
Data Source: Reactome,STRINGDB
NID2
Tbio
Novelty: 0.01638372
Score: 0.991
Data Source: Reactome,STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.99
Data Source: STRINGDB
GPC1
Tbio
Novelty: 0.00293087
Score: 0.981
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  675.85

PubMed score by year
PubTator Score  903.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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