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Tbio
FZD8
Frizzled-8

Protein Summary
Description
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. This intronless gene is a member of the frizzled gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374694
  • ENSP00000363826
  • ENSG00000177283

Symbol
  • FZ-8
  • hFZ8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
biological process
0.88
transcription factor binding site profile
0.87
PubMedID
0.8
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (69)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (111)
1 – 10 of 111
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.999753992
p_ni: 0.00020702
p_wrong: 0.000038988
Score: 0.181
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.983048326
p_ni: 0.015118316
p_wrong: 0.001833358
Score: 0.186
Data Source: BioPlex,STRINGDB
WNT3A
Tchem
Novelty: 0.00119275
Score: 0.991
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.985
Data Source: STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.982
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.981
Data Source: STRINGDB
WNT5A
Tbio
Novelty: 0.00125563
Score: 0.98
Data Source: STRINGDB
RYK
Tbio
Family: Kinase
Novelty: 0.00910227
Score: 0.979
Data Source: STRINGDB
WNT2B
Tbio
Novelty: 0.00783711
Score: 0.974
Data Source: STRINGDB
WNT2
Tbio
Novelty: 0.00313614
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.96

PubMed score by year
PubTator Score  34.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer