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Tbio
PTPN3
Tyrosine-protein phosphatase non-receptor type 3

Protein Summary
Description
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374541
  • ENSP00000363667
  • ENSG00000070159
  • ENST00000412145
  • ENSP00000416654
  • ENST00000446349
  • ENSP00000395384

Symbol
  • PTPH1
  • PTPH1
  • PTP-H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.96
virus perturbation
0.72
microRNA
0.67
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.8   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.8   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
53.8
electrocardiography
1
1
24
24.3
serum albumin measurement
1
1
1
20.5
triglyceride measurement
1
1
1
11.3
glomerular filtration rate
1
1
0
5.7
9.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
53.8
electrocardiography
24
24.3
serum albumin measurement
1
20.5
triglyceride measurement
1
11.3
glomerular filtration rate
0
5.7
9.4
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
EGFR downregulation (R-HSA-182971)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
EGFR downregulation
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
EGFR downregulation
Signal Transduction
Signaling by EGFR
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (58)
1 – 10 of 58
IGFBP1
Tchem
Novelty: 0.0006975
p_int: 0.999994926
p_ni: 0.000004162
p_wrong: 9.12e-7
Score: 0.282
Data Source: BioPlex,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.962
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.942
Data Source: STRINGDB
STAM2
Tbio
Novelty: 0.04440236
Score: 0.915
Data Source: STRINGDB
STAM
Tbio
Novelty: 0.0332731
Score: 0.915
Data Source: STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
Score: 0.914
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.911
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.91
Data Source: STRINGDB
HGS
Tbio
Family: Enzyme
Novelty: 0.00665044
Score: 0.906
Data Source: STRINGDB
EPN1
Tbio
Novelty: 0.01788784
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.80

PubMed score by year
PubTator Score  25.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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