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Tbio
GDF5
Growth/differentiation factor 5

Protein Summary
Description
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374369
  • ENSP00000363489
  • ENSG00000125965
  • ENST00000374372
  • ENSP00000363492

Symbol
  • BMP14
  • CDMP1
  • OS5
  • LAP4
  • BDA1C
  • BMP14
  • CDMP1
  • LAP-4
  • SYM1B
  • SYNS2
  • BMP-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
biological process
0.87
cell type or tissue
0.85
biological term
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.33   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.33   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
4
99.2
BMI-adjusted waist-hip ratio
7
3
11
98.4
osteoarthritis, knee
2
2
0
1.1
96.2
body height
4
3
5
95.1
developmental dysplasia of the hip
1
1
0
1.4
94.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
99.2
BMI-adjusted waist-hip ratio
11
98.4
osteoarthritis, knee
0
1.1
96.2
body height
5
95.1
developmental dysplasia of the hip
0
1.4
94.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 5
VGNC:9861
458202
Mouse
MGI:95688
14563
Rat
RGD:620102
252835
Dog
growth differentiation factor 5
VGNC:41163
485850
Horse
growth differentiation factor 5
VGNC:18291
100034228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 5
Mouse
Rat
Dog
growth differentiation factor 5
Horse
growth differentiation factor 5
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (79)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (123)
1 – 10 of 123
TMEM102
Tbio
Novelty: 0.1239857
p_int: 0.999999991
p_ni: 5e-9
p_wrong: 4e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
SNRK
Tbio
Family: Kinase
Novelty: 0.00707197
p_int: 0.999999949
p_ni: 1.1e-8
p_wrong: 3.9e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
RAB3IP
Tbio
Novelty: 0.04046982
p_int: 0.999999808
p_ni: 1.85e-7
p_wrong: 7e-9
Score: 0.638
Data Source: BioPlex,STRINGDB
FABP4
Tchem
Novelty: 0.00107707
p_int: 0.999999374
p_ni: 7.5e-8
p_wrong: 5.51e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.999969635
p_ni: 0.000030365
Score: 0.231
Data Source: BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty: 0.0167537
p_int: 0.999908088
p_ni: 0.000091912
Score: 0.638
Data Source: BioPlex,STRINGDB
SERPINB7
Tbio
Novelty: 0.01685387
p_int: 0.999900414
p_ni: 0.000099586
Score: 0.166
Data Source: BioPlex,STRINGDB
PLCD1
Tchem
Family: Enzyme
Novelty: 0.00742197
p_int: 0.999833447
p_ni: 0.000165333
p_wrong: 0.00000122
Data Source: BioPlex
PKP3
Tbio
Novelty: 0.0269462
p_int: 0.999734341
p_ni: 0.000265657
p_wrong: 2e-9
Data Source: BioPlex
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.999602847
p_ni: 0.000397153
Data Source: BioPlex
Publication Statistics
PubMed Score  519.33

PubMed score by year
PubTator Score  269.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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