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Tbio
EXTL1
Exostosin-like 1

Protein Summary
Description
Probable glycosyltransferase. This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374280
  • ENSP00000363398
  • ENSG00000158008

Symbol
  • EXTL
  • EXTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
PubMedID
0.6
protein domain
0.58
cellular component
0.53
cell line
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 1
VGNC:11315
469238
Mouse
MGI:1888742
56219
Rat
RGD:1309572
313610
Dog
exostosin like glycosyltransferase 1
VGNC:40533
487363
Horse
exostosin like glycosyltransferase 1
VGNC:17742
100071242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 1
Mouse
Rat
Dog
exostosin like glycosyltransferase 1
Horse
exostosin like glycosyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92935-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Protein-Protein Interactions (31)
1 – 10 of 31
EXTL3
Tbio
Family: Enzyme
Novelty: 0.00714713
Score: 0.956
Data Source: STRINGDB
TRAP1
Tchem
Novelty: 0.03344189
Score: 0.715
Data Source: STRINGDB
B3GALT6
Tbio
Family: Enzyme
Novelty: 0.05220892
Score: 0.654
Data Source: STRINGDB
GLCE
Tbio
Family: Enzyme
Novelty: 0.0497423
Score: 0.612
Data Source: STRINGDB
HS6ST1
Tbio
Family: Enzyme
Novelty: 0.01352454
Score: 0.605
Data Source: STRINGDB
HS6ST3
Tdark
Family: Enzyme
Novelty: 0.14436715
Score: 0.59
Data Source: STRINGDB
XYLT1
Tbio
Family: Enzyme
Novelty: 0.00557591
Score: 0.564
Data Source: STRINGDB
HS2ST1
Tbio
Family: Enzyme
Novelty: 0.04520207
Score: 0.552
Data Source: STRINGDB
B3GAT3
Tbio
Family: Enzyme
Novelty: 0.0289834
Score: 0.539
Data Source: STRINGDB
XYLT2
Tbio
Family: Enzyme
Novelty: 0.00273033
Score: 0.535
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.50

PubMed score by year
PubTator Score  10.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer