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Tbio
UBXN11
UBX domain-containing protein 11

Protein Summary
Description
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314675
  • ENSP00000324721
  • ENSG00000158062
  • ENST00000357089
  • ENSP00000349601
  • ENST00000374217
  • ENSP00000363334
  • ENST00000374221
  • ENSP00000363338
  • ENST00000374222
  • ENSP00000363339

Symbol
  • SOC
  • UBXD5
  • SOC
  • SOCI
  • COA-1
  • UBXD5
  • PP2243
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
transcription factor
0.72
tissue
0.65
cellular component
0.57
tissue sample
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
79.9
platelet count
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
79.9
platelet count
1
18.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 11
VGNC:1718
456657
Macaque
UBX domain protein 11
719826
Mouse
MGI:1914836
67586
Rat
RGD:620769
192207
Dog
UBX domain protein 11
VGNC:48097
487356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 11
Macaque
UBX domain protein 11
Mouse
Rat
Dog
UBX domain protein 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5T124-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (65)
1 – 10 of 65
HSPA7
Tdark
p_int: 0.999982833
p_ni: 4e-8
p_wrong: 0.000017127
Data Source: BioPlex
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999414865
p_ni: 0.000585008
p_wrong: 1.27e-7
Score: 0.787
Data Source: BioPlex,STRINGDB
PDE7A
Tclin
Family: Enzyme
Novelty: 0.00872596
p_int: 0.998193013
p_ni: 0.001120701
p_wrong: 0.000686286
Score: 0.315
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.993963753
p_ni: 0.006036247
Score: 0.558
Data Source: BioPlex,STRINGDB
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.988447075
p_ni: 0.011255477
p_wrong: 0.000297448
Score: 0.534
Data Source: BioPlex,STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
p_int: 0.961414082
p_ni: 0.038585918
Score: 0.189
Data Source: BioPlex,STRINGDB
RTEL1
Tbio
Family: Enzyme
Novelty: 0.00761538
p_int: 0.959216799
p_ni: 0.040783196
p_wrong: 5e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.853441078
p_ni: 0.146558922
Score: 0.534
Data Source: BioPlex,STRINGDB
NPLOC4
Tbio
Novelty: 0.01690434
Score: 0.848
Data Source: STRINGDB
RND3
Tbio
Family: Enzyme
Novelty: 0.00429092
Score: 0.829
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.90

PubMed score by year
PubTator Score  161.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer