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Tbio
GJB1
Gap junction beta-1 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361726
  • ENSP00000354900
  • ENSG00000169562
  • ENST00000374022
  • ENSP00000363134
  • ENST00000374029
  • ENSP00000363141
  • ENST00000646835
  • ENSP00000494596
  • ENST00000647424
  • ENSP00000495960

Symbol
  • CX32
  • CMTX
  • CX32
  • CMTX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
cell type or tissue
0.76
transcription factor perturbation
0.74
chemical
0.73
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 940.47   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 522   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 940.47   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 522   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Oligomerization of connexins into connexons
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Oligomerization of connexins into connexons
Protein-Protein Interactions (75)
1 – 10 of 75
GJB2
Tbio
Novelty: 0.00056398
Score: 0.938
Data Source: Reactome,STRINGDB
MPZ
Tbio
Novelty: 0.00223212
Score: 0.86
Data Source: STRINGDB
PANX3
Tbio
Family: IC
Novelty: 0.0071997
Score: 0.795
Data Source: STRINGDB
PMP22
Tbio
Novelty: 0.00256307
Score: 0.792
Data Source: STRINGDB
PANX2
Tbio
Family: IC
Novelty: 0.00620748
Score: 0.785
Data Source: STRINGDB
PANX1
Tbio
Family: IC
Novelty: 0.00159814
Score: 0.785
Data Source: STRINGDB
CNST
Tdark
Novelty: 0.10372637
Score: 0.771
Data Source: STRINGDB
OCLN
Tbio
Novelty: 0.00047671
Score: 0.77
Data Source: STRINGDB
GJD3
Tbio
Novelty: 0.05441345
Score: 0.757
Data Source: STRINGDB
GJA5
Tbio
Novelty: 0.00195794
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  940.47

PubMed score by year
PubTator Score  546.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer