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Tdark
AHDC1
AT-hook DNA-binding motif-containing protein 1

Protein Summary
Description
This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in individuals with Xia-Gibbs syndrome. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247087
  • ENSP00000247087
  • ENSG00000126705
  • ENST00000374011
  • ENSP00000363123
  • ENST00000642245
  • ENSP00000495072
  • ENST00000642416
  • ENSP00000494394
  • ENST00000644989
  • ENSP00000495665

Symbol
  • MRD25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
small molecule perturbation
0.71
tissue sample
0.69
transcription factor
0.68
cellular component
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999999547
p_ni:  4.53e-7
Data Source:  BioPlex
CSRNP1
Tbio
Novelty:  0.10538864
p_int:  0.99998817
p_ni:  0.000011829
p_wrong:  1e-9
Data Source:  BioPlex
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.983807044
p_ni:  0.016192955
p_wrong:  1e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.97763011
p_ni:  0.004985466
p_wrong:  0.017384424
Data Source:  BioPlex
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.967902935
p_ni:  0.000449514
p_wrong:  0.031647551
Data Source:  BioPlex
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.849711437
p_ni:  0.150288563
Score:  0.163
Data Source:  BioPlex,STRINGDB
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
Score:  0.655
Data Source:  STRINGDB
AGAP6
Tdark
Family:  Enzyme
Novelty:  13.74545455
Score:  0.59
Data Source:  STRINGDB
C1orf109
Tdark
Novelty:  0.93042195
Score:  0.511
Data Source:  STRINGDB
LRRC61
Tdark
Novelty:  1.45343096
Score:  0.499
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
44.2
1
1
0
1.1
15.8
sex hormone-binding globulin measurement
2
1
2
12.7
body mass index
1
1
1
1.7
Calcium channel blocker use measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
44.2
0
1.1
15.8
sex hormone-binding globulin measurement
2
12.7
body mass index
1
1.7
Calcium channel blocker use measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-hook DNA binding motif containing 1
VGNC:53
107975743
Mouse
MGI:2444218
230793
Rat
RGD:1310031
362617
Dog
AT-hook DNA binding motif containing 1
VGNC:37727
487342
Horse
AT-hook DNA binding motif containing 1
VGNC:50646
100056837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-hook DNA binding motif containing 1
Mouse
Rat
Dog
AT-hook DNA binding motif containing 1
Horse
AT-hook DNA binding motif containing 1
Publication Statistics
PubMed Score 18.15
PubMed score by year
PubTator Score 6.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title