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Tchem
DKK1
Dickkopf-related protein 1

Protein Summary
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373970
  • ENSP00000363081
  • ENSG00000107984

Symbol
  • SK
  • DKK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
gene perturbation
1
PubMedID
1
biological process
0.97
transcription factor perturbation
0.88


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.26   (req: < 5)
Gene RIFs: 357   (req: <= 3)
Antibodies: 879   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.26   (req: >= 5)
Gene RIFs: 357   (req: > 3)
Antibodies: 879   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dickkopf‐related protein 1 measurement
1
1
1
22.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dickkopf‐related protein 1 measurement
1
22.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 1
VGNC:1625
450465
Macaque
dickkopf WNT signaling pathway inhibitor 1
702997
Mouse
MGI:1329040
13380
Rat
RGD:1307313
293897
Dog
dickkopf WNT signaling pathway inhibitor 1
VGNC:52929
609600
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 1
Macaque
dickkopf WNT signaling pathway inhibitor 1
Mouse
Rat
Dog
dickkopf WNT signaling pathway inhibitor 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94907-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (72)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Name
Explore in Pharos
Explore in Source
Developmental Biology
Disease
Diseases of signal transduction
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Protein-Protein Interactions (199)
1 – 10 of 199
TK2
Tchem
Family: Kinase
Novelty: 0.10642442
p_int: 0.999999941
p_ni: 1.5e-8
p_wrong: 4.4e-8
Score: 0.516
Data Source: BioPlex,STRINGDB
RBM45
Tbio
Novelty: 0.06739873
p_int: 0.999988461
p_ni: 0.000011539
Score: 0.211
Data Source: BioPlex,STRINGDB
LRP6
Tbio
Novelty: 0.00305615
p_int: 0.999914749
p_ni: 0.000085251
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.998825502
p_ni: 0.001174498
Score: 0.191
Data Source: BioPlex,STRINGDB
LRP5
Tbio
Novelty: 0.00089807
p_int: 0.967197374
p_ni: 0.032802626
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
PSMD6
Tbio
Family: Enzyme
Novelty: 0.04419339
p_int: 0.752298353
p_ni: 0.247701647
Score: 0.22
Data Source: BioPlex,STRINGDB
KREMEN1
Tbio
Novelty: 0.03616334
Score: 0.995
Data Source: STRINGDB
WNT3A
Tchem
Novelty: 0.00119275
Score: 0.992
Data Source: STRINGDB
WNT8A
Tbio
Novelty: 0.01404009
Score: 0.977
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  910.26

PubMed score by year
PubTator Score  678.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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