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Tchem
PTAFR
Platelet-activating factor receptor

Protein Summary
Description
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305392
  • ENSP00000301974
  • ENSG00000169403
  • ENST00000373857
  • ENSP00000362965
  • ENST00000539896
  • ENSP00000442658

Symbol
  • PAFR
  • PAFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.95
molecular function
0.79
cell type or tissue
0.69
biological term
0.67
tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.31   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.31   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 218
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
rupatadine
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
8.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (48)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (409)
1 – 10 of 409
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.934
Data Source: STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.933
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.932
Data Source: STRINGDB
TBXA2R
Tclin
Family: GPCR
Novelty: 0.00571066
Score: 0.931
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.931
Data Source: STRINGDB
LTB4R
Tchem
Family: GPCR
Novelty: 0.00354427
Score: 0.929
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.928
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.928
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.928
Data Source: STRINGDB
LILRB2
Tbio
Novelty: 0.00545569
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  156.31

PubMed score by year
PubTator Score  287.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer