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Tbio
GHRH
Somatoliberin

Protein Summary
Description
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237527
  • ENSP00000237527
  • ENSG00000118702
  • ENST00000373611
  • ENSP00000362713
  • ENST00000373614
  • ENSP00000362716

Symbol
  • GHRF
  • GRF
  • INN
  • GHRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
gene perturbation
0.83
disease
0.66
biological term
0.57
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.08   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.08   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
75.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Gene Ontology Terms (33)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (183)
1 – 10 of 183
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
p_int: 0.994112213
p_ni: 0.001350412
p_wrong: 0.004537375
Data Source: BioPlex
ADD3
Tbio
Family: Enzyme
Novelty: 0.02164464
p_int: 0.814443806
p_ni: 0.185553165
p_wrong: 0.000003029
Data Source: BioPlex
GHRHR
Tclin
Family: GPCR
Novelty: 0.00637611
Score: 0.996
Data Source: Reactome,STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.978
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.977
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.975
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.974
Data Source: STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.97
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.969
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  1757.08

PubMed score by year
PubTator Score  1750.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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