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Tchem
NR5A1
Steroidogenic factor 1

Protein Summary
Description
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a mono ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373588
  • ENSP00000362690
  • ENSG00000136931

Symbol
  • AD4BP
  • FTZF1
  • SF1
  • ELP
  • SF1
  • FTZ1
  • POF7
  • SF-1
  • AD4BP
  • FTZF1
  • SPGF8
  • SRXX4
  • SRXY3
  • hSF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
hub protein
0.9
protein domain
0.85
biological process
0.84
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.45   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.45   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
47.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
47.6
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Nuclear Receptor transcription pathway
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Nuclear Receptor transcription pathway
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (150)
1 – 10 of 150
NR0B1
Tbio
Family: NR
Novelty: 0.00166563
Score: 0.983
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.967
Data Source: Reactome,STRINGDB
PIAS1
Tbio
Family: TF
Novelty: 0.00987743
Score: 0.942
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.937
Data Source: Reactome,STRINGDB
FOXL2
Tbio
Family: TF
Novelty: 0.00224046
Score: 0.936
Data Source: STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.932
Data Source: Reactome,STRINGDB
NRIP1
Tbio
Novelty: 0.00551568
Score: 0.912
Data Source: STRINGDB
PIAS3
Tbio
Family: TF
Novelty: 0.01380668
Score: 0.902
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.9
Data Source: STRINGDB
SOX9
Tbio
Family: TF
Novelty: 0.00047439
Score: 0.891
Data Source: STRINGDB
Publication Statistics
PubMed Score  885.45

PubMed score by year
PubTator Score  607.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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