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Tbio
TBX22
T-box transcription factor TBX22

Protein Summary
Description
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373294
  • ENSP00000362390
  • ENSG00000122145
  • ENST00000373296
  • ENSP00000362393
  • ENST00000619509
  • ENSP00000479825
  • ENSG00000277800
  • ENST00000628957
  • ENSP00000487295

Symbol
  • TBOX22
  • CPX
  • CLPA
  • TBXX
  • ABERS
  • dJ795G23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
phenotype
0.57
biological process
0.55
transcription factor
0.55
gene perturbation
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 22
VGNC:2661
473683
Macaque
T-box 22
708338
Mouse
MGI:2389465
245572
Rat
RGD:1589764
302369
Horse
T-box 22
VGNC:23933
100072559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 22
Macaque
T-box 22
Mouse
Rat
Horse
T-box 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y458-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (53)
1 – 10 of 53
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.959394131
p_ni: 0.040605869
Score: 0.22
Data Source: BioPlex,STRINGDB
CLPP
Tbio
Family: Enzyme
Novelty: 0.00105289
Score: 0.934
Data Source: STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
Score: 0.899
Data Source: STRINGDB
CLPB
Tbio
Family: Enzyme
Novelty: 0.00209789
Score: 0.836
Data Source: STRINGDB
SMCP
Tbio
Novelty: 0.04350183
Score: 0.76
Data Source: STRINGDB
SP100
Tbio
Family: TF; Epigenetic
Novelty: 0.00201806
Score: 0.712
Data Source: STRINGDB
SHOX2
Tbio
Family: TF
Novelty: 0.01090989
Score: 0.686
Data Source: STRINGDB
YME1L1
Tbio
Family: Enzyme
Novelty: 0.00180835
Score: 0.669
Data Source: STRINGDB
CLPS
Tbio
Family: Enzyme
Novelty: 0.00246852
Score: 0.649
Data Source: STRINGDB
MSX1
Tbio
Family: TF
Novelty: 0.00176212
Score: 0.648
Data Source: STRINGDB
Publication Statistics
PubMed Score  117.13

PubMed score by year
PubTator Score  85.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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