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Tchem
FPGS
Folylpolyglutamate synthase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373225
  • ENSP00000362322
  • ENSG00000136877
  • ENST00000373247
  • ENSP00000362344
  • ENST00000393706
  • ENSP00000377309
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
molecular function
0.86
transcription factor binding site profile
0.79
protein domain
0.73
transcription factor
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.57   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.57   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
folylpolyglutamate synthase
VGNC:4740
739997
Macaque
folylpolyglutamate synthase
699587
Mouse
MGI:95576
14287
Rat
RGD:1587713
687266
Dog
folylpolyglutamate synthase
VGNC:40973
100855785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
folylpolyglutamate synthase
Macaque
folylpolyglutamate synthase
Mouse
Rat
Dog
folylpolyglutamate synthase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q05932-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
PALM2
Tbio
Novelty: 0.03469098
p_int: 0.999999756
p_ni: 2.43e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.02741994
p_int: 0.999956666
p_ni: 0.000043334
Score: 0.313
Data Source: BioPlex,STRINGDB
THEM4
Tbio
Family: Enzyme
Novelty: 0.0191855
p_int: 0.998257037
p_ni: 0.001596583
p_wrong: 0.00014638
Score: 0.189
Data Source: BioPlex,STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.996535973
p_ni: 0.003464026
p_wrong: 1e-9
Data Source: BioPlex
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.990396331
p_ni: 0.009405446
p_wrong: 0.000198223
Score: 0.168
Data Source: BioPlex,STRINGDB
NIT1
Tbio
Family: Enzyme
Novelty: 0.00498587
p_int: 0.87850308
p_ni: 0.003017059
p_wrong: 0.118479861
Score: 0.272
Data Source: BioPlex,STRINGDB
DHFR
Tclin
Family: Enzyme
Novelty: 0.00074557
Score: 0.99
Data Source: STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.986
Data Source: STRINGDB
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
Score: 0.986
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  94.57

PubMed score by year
PubTator Score  183.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer