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Tbio
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Endoglin

Protein Summary
Description
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344849
  • ENSP00000341917
  • ENSG00000106991
  • ENST00000373203
  • ENSP00000362299

Symbol
  • END
  • END
  • HHT1
  • ORW1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
biological process
0.95
molecular function
0.93
transcription factor perturbation
0.74
biological term
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2630.55   (req: < 5)
Gene RIFs: 382   (req: <= 3)
Antibodies: 2186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2630.55   (req: >= 5)
Gene RIFs: 382   (req: > 3)
Antibodies: 2186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
2
3
84.2
hemoglobin measurement
2
2
2
62.2
red blood cell density measurement
1
1
1
31.2
erythrocyte count
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
84.2
hemoglobin measurement
2
62.2
red blood cell density measurement
1
31.2
erythrocyte count
1
2.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TGF_beta_Receptor
PathwayCommons: pid
ALK1 signaling events
PathwayCommons: pid
HIF-1-alpha transcription factor network
Name
Explore in Pharos
Explore in Source
TGF_beta_Receptor
ALK1 signaling events
HIF-1-alpha transcription factor network
Gene Ontology Terms (76)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (214)
1 – 10 of 214
ACVRL1
Tchem
Family: Kinase
Novelty: 0.00310167
Score: 0.993
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.989
Data Source: STRINGDB
GDF2
Tbio
Novelty: 0.00433233
Score: 0.989
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.982
Data Source: STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.977
Data Source: STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.973
Data Source: STRINGDB
TGFB3
Tbio
Novelty: 0.00068568
Score: 0.966
Data Source: STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
Score: 0.963
Data Source: STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
Score: 0.96
Data Source: STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  2630.55

PubMed score by year
PubTator Score  1674.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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