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Tbio
POU3F4
POU domain, class 3, transcription factor 4

Protein Summary
Description
Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373200
  • ENSP00000362296
  • ENSG00000196767

Symbol
  • BRN4
  • OTF9
  • BRN4
  • DFN3
  • OTF9
  • BRN-4
  • DFNX2
  • OCT-9
  • OTF-9
  • BRAIN-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.59
gene perturbation
0.51
transcription factor
0.51
cell line
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.83   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.83   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
5.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 3 homeobox 4
VGNC:1201
100615412
Macaque
POU class 3 homeobox 4
710157
Mouse
MGI:101894
18994
Rat
RGD:61947
29589
Dog
POU class 3 homeobox 4
VGNC:44830
491988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 3 homeobox 4
Macaque
POU class 3 homeobox 4
Mouse
Rat
Dog
POU class 3 homeobox 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49335-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
DNAAF4
Tbio
Novelty:  0.01730685
Score:  0.715
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.704
Data Source:  STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
Score:  0.7
Data Source:  STRINGDB
NPAS3
Tbio
Family:  TF
Novelty:  0.02597048
Score:  0.687
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.677
Data Source:  STRINGDB
DIAPH2
Tbio
Novelty:  0.02008076
Score:  0.621
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.602
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.601
Data Source:  STRINGDB
KCNE5
Tbio
Novelty:  0.06395873
Score:  0.594
Data Source:  STRINGDB
RAB40AL
Tbio
Novelty:  0.00908832
Score:  0.584
Data Source:  STRINGDB
Publication Statistics
PubMed Score  127.83

PubMed score by year
PubTator Score  137.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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