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Tbio
MOCS1
Molybdenum cofactor biosynthesis protein 1

Protein Summary
Description
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related ps ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340692
  • ENSP00000344794
  • ENSG00000124615
  • ENST00000373181
  • ENSP00000362277
  • ENST00000373188
  • ENSP00000362284
  • ENST00000373195
  • ENSP00000362291

Symbol
  • MIG11
  • MOCOD
  • MOCS1A
  • MOCS1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
pathway
0.78
cell type or tissue
0.69
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Molybdenum cofactor biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Molybdenum cofactor biosynthesis
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (134)
1 – 10 of 134
OXLD1
Tdark
Family: Enzyme
p_int: 0.999997058
p_ni: 0.000002942
Data Source: BioPlex
CHCHD4
Tbio
Novelty: 0.01246396
p_int: 0.999940701
p_ni: 0.000059298
p_wrong: 1e-9
Data Source: BioPlex
PDGFRL
Tbio
Novelty: 0.08439408
p_int: 0.999799106
p_ni: 0.000200893
Data Source: BioPlex
UROS
Tbio
Family: Enzyme
Novelty: 0.00310158
p_int: 0.99898598
p_ni: 0.001013985
p_wrong: 3.5e-8
Score: 0.394
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.10510475
p_int: 0.998611417
p_ni: 0.001388556
p_wrong: 2.7e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
PF4
Tbio
Novelty: 0.00046898
p_int: 0.997816173
p_ni: 0.002183779
p_wrong: 4.8e-8
Data Source: BioPlex
HINT2
Tbio
Novelty: 0.0404157
p_int: 0.997112675
p_ni: 0.002886525
p_wrong: 7.99e-7
Data Source: BioPlex
TINAG
Tbio
Novelty: 0.04045398
p_int: 0.996485196
p_ni: 0.002142175
p_wrong: 0.001372629
Data Source: BioPlex
CCDC120
Tbio
Novelty: 0.71428571
p_int: 0.993787452
p_ni: 0.005434502
p_wrong: 0.000778046
Data Source: BioPlex
RAB17
Tbio
Family: Enzyme
Novelty: 0.05572289
p_int: 0.991968868
p_ni: 0.007935728
p_wrong: 0.000095404
Score: 0.239
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.52

PubMed score by year
PubTator Score  21.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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