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Tbio
INPP5B
Type II inositol 1,4,5-trisphosphate 5-phosphatase

Protein Summary
Description
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373023
  • ENSP00000362114
  • ENSG00000204084
  • ENST00000373024
  • ENSP00000362115
  • ENST00000373026
  • ENSP00000362117
  • ENST00000373027
  • ENSP00000362118

Symbol
  • OCRL2
  • 5PTase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
cellular component
0.8
histone modification site profile
0.75
transcription factor binding site profile
0.72
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
2
51.9
autoimmune thyroid disease
1
1
0
1.1
38.3
body height
1
1
1
34
Thyroid preparation use measurement
1
1
1
26.2
red blood cell distribution width
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
51.9
autoimmune thyroid disease
0
1.1
38.3
body height
1
34
Thyroid preparation use measurement
1
26.2
red blood cell distribution width
1
11.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase B
VGNC:8054
456767
Macaque
inositol polyphosphate-5-phosphatase B
716851
Mouse
MGI:103257
16330
Rat
RGD:1311511
362590
Dog
inositol polyphosphate-5-phosphatase B
VGNC:42031
100686373
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase B
Macaque
inositol polyphosphate-5-phosphatase B
Mouse
Rat
Dog
inositol polyphosphate-5-phosphatase B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32019-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
PHETA2
Tbio
Novelty: 2.16796164
p_int: 0.999999997
p_ni: 3e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
PHETA1
Tbio
Novelty: 0.52415295
p_int: 0.99999996
p_ni: 3.8e-8
p_wrong: 1e-9
Score: 0.967
Data Source: BioPlex,STRINGDB
OCRL
Tbio
Family: Enzyme
Novelty: 0.00555539
p_int: 0.998935319
p_ni: 6.8e-7
p_wrong: 0.001064001
Score: 0.971
Data Source: BioPlex,STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.967
Data Source: STRINGDB
INPP4A
Tbio
Family: Enzyme
Novelty: 0.03714963
Score: 0.959
Data Source: STRINGDB
INPP4B
Tbio
Family: Enzyme
Novelty: 0.02053228
Score: 0.946
Data Source: STRINGDB
TPTE2
Tbio
Family: Enzyme
Novelty: 0.04710658
Score: 0.933
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.933
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.933
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.14

PubMed score by year
PubTator Score  11.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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