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Tbio
MFSD2A
Sodium-dependent lysophosphatidylcholine symporter 1

Protein Summary
Description
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhib ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372809
  • ENSP00000361895
  • ENSG00000168389
  • ENST00000372811
  • ENSP00000361898

Symbol
  • MFSD2
  • NLS1
  • NLS1
  • MFSD2
  • MCPH15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.7
histone modification site profile
0.68
tissue sample
0.68
PubMedID
0.64
transcription factor binding site profile
0.62


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.02   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.02   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
33.5
mean corpuscular volume
1
1
1
30.2
red blood cell distribution width
1
1
1
28
hematocrit
1
1
1
23.4
triglyceride measurement
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
33.5
mean corpuscular volume
1
30.2
red blood cell distribution width
1
28
hematocrit
1
23.4
triglyceride measurement
1
0.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 2A
VGNC:1320
456787
Macaque
major facilitator superfamily domain containing 2A
718876
Mouse
MGI:1923824
76574
Rat
RGD:1310174
298504
Dog
major facilitator superfamily domain containing 2A
VGNC:43200
475318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 2A
Macaque
major facilitator superfamily domain containing 2A
Mouse
Rat
Dog
major facilitator superfamily domain containing 2A
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (51)
1 – 10 of 51
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
ERVFRD-1
Tbio
Novelty: 0.02645962
Score: 0.757
Data Source: STRINGDB
MFSD11
Tdark
Novelty: 0.13167358
Score: 0.676
Data Source: STRINGDB
SVOPL
Tdark
Novelty: 0.46448049
Score: 0.668
Data Source: STRINGDB
SVOP
Tbio
Novelty: 0.0830639
Score: 0.666
Data Source: STRINGDB
SLC25A33
Tbio
Family: Transporter
Novelty: 0.17554778
Score: 0.638
Data Source: STRINGDB
SYCP2L
Tdark
Novelty: 0.19013847
Score: 0.637
Data Source: STRINGDB
MFSD10
Tbio
Novelty: 0.12830664
Score: 0.623
Data Source: STRINGDB
MFSD4B
Tdark
Novelty: 0.03380333
Score: 0.617
Data Source: STRINGDB
MFSD5
Tdark
Novelty: 0.58146966
Score: 0.603
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.02

PubMed score by year
PubTator Score  52.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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