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Tchem
TIE1
Tyrosine-protein kinase receptor Tie-1

Protein Summary
Description
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372476
  • ENSP00000361554
  • ENSG00000066056
  • ENST00000538015
  • ENSP00000440063

Symbol
  • TIE
  • TIE
  • JTK14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
PubMedID
0.73
co-expressed gene
0.69
tissue sample
0.65


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.3   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 664   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.3   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 664   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
85.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine kinase with immunoglobulin like and EGF like domains 1
VGNC:7007
469308
Macaque
tyrosine kinase with immunoglobulin like and EGF like domains 1
702208
Mouse
MGI:99906
21846
Rat
RGD:621642
89806
Dog
tyrosine kinase with immunoglobulin like and EGF like domains 1
VGNC:47366
482535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine kinase with immunoglobulin like and EGF like domains 1
Macaque
tyrosine kinase with immunoglobulin like and EGF like domains 1
Mouse
Rat
Dog
tyrosine kinase with immunoglobulin like and EGF like domains 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35590-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (181)
Items per page:
1 – 5 of 181
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
RAC1/PAK1/p38/MMP2 Pathway
WikiPathways
RAC1/PAK1/p38/MMP2 Pathway
WikiPathways
RAC1/PAK1/p38/MMP2 Pathway
WikiPathways
RAC1/PAK1/p38/MMP2 Pathway
WikiPathways
RAC1/PAK1/p38/MMP2 Pathway
Name
Explore in Pharos
Explore in Source
RAC1/PAK1/p38/MMP2 Pathway
RAC1/PAK1/p38/MMP2 Pathway
RAC1/PAK1/p38/MMP2 Pathway
RAC1/PAK1/p38/MMP2 Pathway
RAC1/PAK1/p38/MMP2 Pathway
Protein-Protein Interactions (52)
1 – 10 of 52
CFI
Tbio
Novelty: 0.00271423
Score: 0.827
Data Source: STRINGDB
ANGPT2
Tbio
Novelty: 0.00116183
Score: 0.821
Data Source: STRINGDB
ANGPT1
Tbio
Novelty: 0.00115408
Score: 0.78
Data Source: STRINGDB
ANGPT4
Tbio
Novelty: 0.02566013
Score: 0.776
Data Source: STRINGDB
ANGPTL1
Tbio
Novelty: 0.03123564
Score: 0.755
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.723
Data Source: STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.715
Data Source: STRINGDB
PECAM1
Tbio
Novelty: 0.00013373
Score: 0.665
Data Source: STRINGDB
ANGPTL2
Tbio
Novelty: 0.01134724
Score: 0.652
Data Source: STRINGDB
ANGPTL3
Tbio
Novelty: 0.00595539
Score: 0.63
Data Source: STRINGDB
Publication Statistics
PubMed Score  176.30

PubMed score by year
PubTator Score  95.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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