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Tbio
PRRX2
Paired mesoderm homeobox protein 2

Protein Summary
Description
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372469
  • ENSP00000361547
  • ENSG00000167157

Symbol
  • PMX2
  • PRX2
  • PMX2
  • PRX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
PubMedID
0.66
tissue sample
0.61
transcription factor
0.59
virus perturbation
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired related homeobox 2
VGNC:4831
464792
Mouse
MGI:98218
20204
Rat
RGD:1311471
113931
Dog
paired related homeobox 2
VGNC:49775
491298
Horse
paired related homeobox 2
VGNC:21913
100069960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired related homeobox 2
Mouse
Rat
Dog
paired related homeobox 2
Horse
paired related homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99811-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (45)
1 – 10 of 45
HOXB13
Tbio
Family: TF
Novelty: 0.00644371
Score: 0.811
Data Source: STRINGDB
PAX9
Tbio
Family: TF
Novelty: 0.00581813
Score: 0.731
Data Source: STRINGDB
C9orf78
Tdark
Novelty: 0.63248782
Score: 0.687
Data Source: STRINGDB
TBX15
Tbio
Family: TF
Novelty: 0.03198241
Score: 0.624
Data Source: STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00748285
Score: 0.59
Data Source: STRINGDB
DKKL1
Tbio
Novelty: 0.00544618
Score: 0.568
Data Source: STRINGDB
FOXF2
Tbio
Family: TF
Novelty: 0.02032168
Score: 0.568
Data Source: STRINGDB
TGM6
Tchem
Family: Enzyme
Novelty: 0.00766073
Score: 0.566
Data Source: STRINGDB
METTL11B
Tdark
Family: Enzyme
Novelty: 0.40358021
Score: 0.564
Data Source: STRINGDB
TMEM9
Tbio
Novelty: 0.06916197
Score: 0.561
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.89

PubMed score by year
PubTator Score  21.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer