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Tbio
TSC22D3
TSC22 domain family protein 3

Protein Summary
Description
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315660
  • ENSP00000314655
  • ENSG00000157514
  • ENST00000372383
  • ENSP00000361458
  • ENST00000372384
  • ENSP00000361459
  • ENST00000372397
  • ENSP00000361474
  • ENST00000506081
  • ENSP00000427427

Symbol
  • DSIPI
  • GILZ
  • DIP
  • GILZ
  • DSIPI
  • TSC-22R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.92
PubMedID
0.91
gene perturbation
0.84
histone modification site profile
0.81
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.97   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.97   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TSC22 domain family member 3
702656
Mouse
MGI:1196284
14605
Rat
RGD:621654
83514
Horse
TSC22 domain family member 3
VGNC:24573
100054678
Platypus
TSC22 domain family member 3
100073399
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TSC22 domain family member 3
Mouse
Rat
Horse
TSC22 domain family member 3
Platypus
TSC22 domain family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99576-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (95)
1 – 10 of 95
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.999999998
p_ni: 2e-9
Score: 0.831
Data Source: BioPlex,STRINGDB
TSC22D2
Tdark
Family: TF
Novelty: 0.30718123
p_int: 0.999998718
p_ni: 0.000001282
Score: 0.866
Data Source: BioPlex,STRINGDB
TSC22D1
Tbio
Family: TF
Novelty: 0.01934962
p_int: 0.999991659
p_ni: 0.00000834
p_wrong: 1e-9
Score: 0.845
Data Source: BioPlex,STRINGDB
SYNJ2BP
Tbio
Novelty: 0.02520087
p_int: 0.999498014
p_ni: 0.000493256
p_wrong: 0.000008731
Data Source: BioPlex
NRBP1
Tbio
Family: Kinase
Novelty: 0.05902656
p_int: 0.99594325
p_ni: 0.00405675
Score: 0.837
Data Source: BioPlex,STRINGDB
RCCD1
Tbio
Novelty: 0.07481641
p_int: 0.994430804
p_ni: 0.005569196
Data Source: BioPlex
FAM117B
Tdark
Novelty: 1.06316483
p_int: 0.985746984
p_ni: 0.014253015
p_wrong: 1e-9
Score: 0.804
Data Source: BioPlex,STRINGDB
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.971609453
p_ni: 0.028390461
p_wrong: 8.5e-8
Data Source: BioPlex
CEP55
Tbio
Novelty: 0.01328073
p_int: 0.953407528
p_ni: 0.045280785
p_wrong: 0.001311687
Score: 0.169
Data Source: BioPlex,STRINGDB
CDC42SE2
Tbio
Novelty: 0.04549938
p_int: 0.940882187
p_ni: 0.059117813
Score: 0.309
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  213.97

PubMed score by year
PubTator Score  89.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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